Subsequently, p-STAT3 can induce the downstream target genes, such as CCL2, CCL5, ICAM-1, SNAI1, chitinase-3-like 1 (CHI3L1), FBJ murine osteosarcoma viral oncogene homolog (FOS), and Skp2, that promote various cellular processes for cancer progression [52–54]. The gene discussed is CCL2; the disease is cancer.