Therefore, we may speculate that EXP3179 may improve LV function by inhibiting CTGF-dependent pro-fibrotic mechanisms in cardiac fibroblasts, with a mild anti-hypertensive effect, whereas EXP3174 may improve LV function through normalization of BP with a concomitant, mild inhibitory effect on myocardial fibrosis. The gene discussed is CCN2; the disease is Myocardial fibrosis.