Therefore, we have investigated the effects of EXP3179 and EXP3174 on fibrosis, and LOX and CCL in the myocardium of rats with arterial hypertension induced by the NG-nitro-L-arginine methyl ester (L-NAME), an experimental model characterized by myocardial transforming growth factor-β1 (TGF-β1) overexpression and fibrosis17, 18, 19. The gene discussed is LOX; the disease is Hypertension.