The IL1B-CGTC (N°3) haplotype found to be associated with an increased risk of CRC in Colombian subjects from the Coastal region was also the most frequent haplotype in the self-reported African American CRC cases from this study and the African Americans from the Atherosclerosis Risk Communities Cohort (ARIC)10 (Supplementary Table S4). The gene discussed is IL1B; the disease is colorectal carcinoma.