IL1B and alkaline phosphatase measurement: We found that AP risk was mainly explained by the effect of global European ancestry (OR 1.91; 95% CI 1.17–3.13; p = 0.01; Model 7b) and that the data suggested an association with AP risk for the IL1B-TGCT haplotype copies (95% CI 0.83–2.66; Model 4b).