Osteonectin (also known as SPARC) is an adhesive calcium-binding ECM glycoprotein that binds various ECM components such as TSP-1 and fibrillar collagens.90 In adults, osteonectin is expressed during processes requiring ECM turnover such as wound healing and tumor progression.90 Osteonectin prevents cell spreading in vitro suggesting they play an important role in cellular proliferation and migration.91 High levels of tissue osteonectin has been associated with reduced collagen type IV deposition.92 Here, SPARC is linked to neoplasm.