Recently, a BiTE construct comprised of the scFv fragments of antibodies specific for CD3 and WT1 epitope RMF in the context of HLA-A*02:01 (WT1-BiTE) was made.46 This BiTE could bind to WT1(+) and HLA-A*02:01(+)AML targets and activate T cells to proliferate and kill the leukemic cells in vitro and in immunodeficient mice. The gene discussed is WT1; the disease is acute myeloid leukemia.