CD45 is expressed on all hematopoietic cells except mature red blood cells and platelets.61 A recombinant bispecific antibody was generated comprising a scFv against the radiometal complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA, a metal chelating agent) and a CD45 binding moiety containing the light chain of an anti-CD45 antibody and the heavy chain of rituximab.62Invivo targeting was performed in human-AML-bearing mice after injecting the antibody construct, followed by administering a clearing agent after 22 h and finally injecting the yttrium-90-labeled DOTA. The gene discussed is PTPRC; the disease is acute myeloid leukemia.