Treatment of NK cells with an ADAM17 inhibitor and CD16 × CD33 BiKE prevented CD16 shedding from NK-cell surface, thereby enhancing NK-cell cytokine secretion and cytotoxicity.25 This BiKE was further tested using NK-cell samples from patients with myelodysplastic syndrome (MDS) where the NK-cell frequency and their CD16 expression were low. The gene discussed is CD33; the disease is myelodysplastic syndrome.