IL6 and acute myeloid leukemia: In cynomolgus macaques, MGD006 produced transient IL-6 release and reversible decrease in the red blood cell mass.42 In humanized NSG mice, MGD006 was effective against xenografts derived from a leukemic cell line or from primary AML samples.43 A first in human study is ongoing in AML patients (ClinicalTrials.gov identifier NCT02152956).