It contains an extracellular IgV domain next to a five-fold-passing transmembrane domain and a short cytoplasmic sequence.63 CD47 binding to signal regulatory protein-α expressed on dendritic cells and macrophages delivers a signal which inhibits phagocytosis.64 CD47 is a leukemia stem cell (LSC) marker and its overexpression in AML has been associated with poor survival.65 Recently, a bispecific antibody was generated to target CD47 and CD20 to treat lymphoma. Here, CD47 is linked to leukemia.