CD13 has several roles including tumor cell invasion, adhesion, differentiation, proliferation, apoptosis, motility, phagocytosis and angiogenesis.49 Monoclonal antibodies targeting CD13 result in apoptosis of primary AML cells and cell lines.50 In an attempt to target CD13 in AML, a bispecific antibody was generated by chemically conjugating the anti-CD3 and anti-CD13 Fab' fragments. Here, ANPEP is linked to acute myeloid leukemia.