In this review, we summarize those AML targets for which bispecific antibodies have been developed, in descending order of clinical relevance: CD33, CD123, Wilms' tumor protein (WT1), CD13, CD15, CD30, CD45, CD47, C-type lectin-like molecule 1 (CLL1), Fms-like tyrosine kinase 3 (FLT-3) and angiogenic growth factors. Here, PTPRC is linked to acute myeloid leukemia.