Six patients that carry missense mutations in TP53 could potentially benefit from agents that restore the active conformation of mutant p53 and induce p53-dependent suppression of tumor cell growth as currently being tested in other cancer indications.53, 54 We are currently developing xenograft models of genetically well-defined leukemias that will allow correlating the mutational profile with drug sensitivity and will thus enable us to directly test the potential to use the signature reported here to design new targeted treatment strategies. Here, TP53 is linked to cancer.