It has long been known that classically activated macrophages display antitumor cytotoxic and cytostatic effects19, 20, 21 and it has previously been shown that coculture with apoptotic cells can reduce the ability of classically activated BMDMs to induce cell death.22 To determine the effects of apoptotic lymphoma cell-conditioned M(IFN-γ/LPS) macrophages on the lymphoma cell-birth/cell-death equation, we designed the protocol summarized in Figure 4a. This evidence concerns the gene IFNG and lymphoma.