LGALS3 and non-Hodgkin lymphoma: Impairment of the antitumor capacity of galectin-3-deficient M(IFN-γ/LPS) macrophages in vitro suggested that galectin-3 may be important in innate antitumor immunity in NHL as has been indicated in other models.25, 26 Conversely, the upregulation of galectin-3 gene expression in SS-TAMs may support the argument that galectin-3 imparts protumor activity.