AITL tumor cells share characteristics with TFH cells, expressing B-cell lymphoma protein 6, a transcription factor; C-C motif chemokine receptor 5, a chemokine receptor; C-X-C motif ligand 13, a chemokine; and programmed death-1 (PD1), a member of the CD28 costimulatory membrane receptor family.4, 5 AITL tissues display prominent infiltration of inflammatory cells, follicular dendritic cell meshwork formation and branching vascular structures. The gene discussed is CD28; the disease is angioimmunoblastic T-cell lymphoma.