To gain further insight into the origin of the G17V RHOA mutation, we examined the mutation in laser-microdissected PD1+ and CD20+ B cells, which were assumed to be enriched and depleted in tumor cells, respectively, in 10 nodal T-cell lymphomas (1 nodal PTCL with TFH phenotype and 9 AITL cases). Here, RHOA is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.