This hypothesis is based on the fact that identical TET2 and DNMT3A mutations were found in both tumor tissues and apparently normal blood cells in some AITL and PTCL-NOS patients.8, 10, 15, 16, 17 In contrast, the origins of the G17V RHOA mutation remain to be elucidated: it may be a tumor-specific event, considering that the allele frequencies of G17V RHOA mutations were lower than those of TET2 mutations and that G17V RHOA mutations were found in only CD4+T lymphocytes in 1 AITL and 1 PTCL-NOS case.8 This evidence concerns the gene CD4 and angioimmunoblastic T-cell lymphoma.