Since MYXV is currently being developed as oncolytic virus for many classes of human cancers, a more detailed understanding of how MYXV responds to IFN activities in different host species and in cell types of varying lineages will help to provide more mechanistic explanations for why the virus is utterly rabbit-specific in nature, but also possesses an apparently expanded tropism for cancer cells and tissues in mice and humans [10,11,12]. Here, IFNA1 is linked to cancer.