Of note, apoptotic cell-derived EVs characterized by the exposure of galectin-3-binding protein (G3BP), which may interact with specific extracellular matrix proteins at the glomerular basement membrane, have been detected in the glomeruli of kidney biopsies of SLE patients where they colocalize with IgG [66], further supporting the pathogenic role of EVs in SLE autoimmunity. The gene discussed is G3BP1; the disease is systemic lupus erythematosus.