GAN and systemic lupus erythematosus: In systemic lupus erythematosus (SLE), a systemic autoimmune disease characterized by elevated levels of circulating anti-DNA antibodies, which ultimately lead to immune complex deposition and tissue destruction [58], a higher number of plasma EVs bearing immunoglobulins (Igs) G can be found compared with healthy controls, and interestingly, they correlate with anti-DNA antibody levels [59].