TGFB1 and experimental autoimmune encephalomyelitis: In agreement with the direct effect of TGF-β1 EVs derived from DCs on Treg cell differentiation and function, Yu et al. [32] demonstrated that treatment of experimental autoimmune encephalomyelitis (EAE) mice with EVs carrying membrane-associated TGF-β1 corrects the imbalance between Th17 and Treg cells by preventing Th17 cell development and promoting Treg cell expansion.