Interestingly, we noticed that knockdown of ZFX suppressed the expression of several important β‐catenin target genes such as c‐Myc, c‐Jun, and cyclin D1 in hepatoma cells, whereas enforced expression of ZFX upregulated these downstream effectors both in mRNA and protein levels (Fig. 6A,B). Here, ZFX is linked to hepatocellular carcinoma.