CD40LG and neoplasm: In the same way in which the presence of neo-epitopes in certain malignant tumor cells and the presence of IgMs directed against these neo-epitopes is a recent field of study in the therapy and diagnosis of cancerous processes25, 41, 42, so the existence of neo-epitopes on CA and other degenerative brain structures and the presence of natural IgM antibodies directed against them could become a new focus of the study of age-related or pathological degenerative brain processes.