In this research, we constructed a novel complex using gold nanorods (GNRs) coated with porphyrin as well as anti-HER2 antibody (trastuzumab) called GNRs-porphyrin-trastuzumab complexes (TGNs) and investigated the efficiency of this complex in targeting and photothermally ablating of HER2-positive breast cancer in vitro and vivo. The gene discussed is ERBB2; the disease is breast cancer.