Moreover, Carpin and colleagues10 have investigated the impact of anti-HER2-conjugated silica-gold nanoshell on trastuzumab-resistant breast cancer cell lines, and they reported that these nanoshell complexes could effectively target trastuzumab-resistant cells and induce laser ablation, thus providing bright hope of using nanomaterials treating drug-resistance cancer patients. This evidence concerns the gene ERBB2 and breast cancer.