Moreover, with wider variant cross-recognition capacity, broader T cell responses and stronger functionality profiles, high functional avidity CD8+ T cells also triggered effector functions more readily and undergo promptly expansion in vivo, help shaping their immunodominance4, 7, 8, 9, 10, 11, leading to an efficient viral infected cells clearance12, 13, 14 and tumor cells elimination15, 16. The gene discussed is CD8A; the disease is neoplasm.