ASGR1 and hepatocellular carcinoma: As Pul and AGn are known ASGPR ligands (Prescott et al., 1995; Rekha & Sharma, 2011), in the present study, we evaluate PES-Gantrez® AN 119 Dox NPs anchored with Pul, AGn, and a combination of Pul with AGn (Pul-AGn) as ligands for ASGPR-mediated hepatocyte targeted delivery in vitro and anticancer efficacy in PLC/PRF/5 liver tumor-bearing Nod/Scid mice as a preclinical xenograft model of HCC.