REN and hypertensive disorder: An inverse relationship, often age related, between vitamin D status and systolic blood pressure has been described and links lower serum 25-hydroxy vitamin D [25(OH)D] levels with a higher risk of hypertension.5,6,7,8 Vitamin D seems to act as a negative regulator of the renin gene,9 with a vitamin D deficiency promoting an increase in blood pressure by increasing the expression of renin.