CAR expressing effector cells can recognize tumor cells in a Major Histocompatibility Complex/Human Leukocyte Antigen (MHC-HLA) independent manner; thus the recognition of tumor cells is not affected by two key tumor escape mechanisms: downregulation of MHC Class 1 or Class 2 molecules and altered antigen processing [106, 112, 113]. This evidence concerns the gene HLA-C and neoplasm.