Consequently, according to the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association of Molecular Pathologists, it is recommended that, whenever feasible, all advanced NSCLC patients with elements of the adenocarcinoma histological subtype should be screened for EGFR mutations and ALK fusions in order to guide therapy selection (15). The gene discussed is ALK; the disease is non-small cell lung carcinoma.