In addition, the obesity state per se is associated with the ability for leptin to properly access and regulates central neural substrate and is refereed as to “leptin resistance.” “Leptin resistance” is characterized with a state of reduced responsiveness to plasma leptin, hampering the inhibition of food intake (Zhang et al., 1994; Lee et al., 2001; Farooqi, 2006). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.