Administration of CB2 agonist can reduce the infract size of the brain and motor functional deficits and restrain the production of adhesion factor and matrix metalloproteinases, inhibit the inflammatory response, and improve the microcirculation after cerebral ischemia (Fernández-Ruiz et al., 2007; Benito et al., 2008; Pini et al., 2012). Here, CNR2 is linked to Cerebral ischemia.