Assessment of Aβ and amyloid-plaques using the FCA3340 antibody, which specifically recognizes human Aβ but not APP (Barelli et al., 1997), indicated no immunolabeling in hippocampus sections obtained from 1 month-old TgCRND8 mice, in contrast to the abundance of plaques present in the hippocampus of 11 month-old TgCRND8 mice, used as a positive control (Chishti et al., 2001; Figure 1B). The gene discussed is APP; the disease is amyloidosis.