MAPT and Alzheimer disease: The proteins directly involved in prion-like diseases [Amyloid β (Aβ) for AD, tau for tauopathies, and α-synuclein (α-syn) for synucleinopathies] show similarities to prion protein in terms of the mechanism of seeding (Yamamoto et al., 2005; Nonaka et al., 2010) and spreading (Frost et al., 2009; Hansen et al., 2011) and of cell interaction modalities (Yamamoto et al., 2005; Nonaka et al., 2010).