A causative role for α-syn in the development of synucleinopathies has been established in PD via the discovery of mutations in the α-syn gene SNCA (A30P, E46K, H50Q, G51D, and A53T) resulting in autosomal-dominant PD (Kruger et al., 1998; Zarranz et al., 2004; Appel-Cresswell et al., 2013; Lesage et al., 2013; Proukakis et al., 2013; Pasanen et al., 2014). The gene discussed is SNCA; the disease is synucleinopathy.