Look at the top three somatic mutant genes of this pathway in human CRC, there were TP53 with 44.6% in Total, 49.1% in MSS, and 32.8% in MSI, KRAS with 41.5% in Total, 45.3% in MSS and 32.8% in MSI and PIK3CA with 12.5% in Total, 11.9% in MSS and 14.1% in MSI, however, none of them was detected in AOM/DSS mice. The gene discussed is KRAS; the disease is colorectal carcinoma.