And 3) We selected the top 20 most frequently mutated sites among TCGA samples, all of which were located within the driver genes of CRC including APC, TP53, KRAS, NRAS, BRAF, PIK3CA, SMAD4 and FBXW7, and mapped them to the mouse exome sequencing data. This evidence concerns the gene KRAS and colorectal carcinoma.