Interestingly, the brain-specific expressions of both RP1-269M15.3 and TOX2 were highly correlated (r ≥ .70) with a number of depression-related genes (e.g., LRFN5, GRM7, CRH) (47, 48) in brain development (http://brainspan.org) (Supplemental Tables S14 and S15), suggesting that the expression networks involving those genes were potential targets of the effects from candidate variants. This evidence concerns the gene TOX2 and major depressive disorder.