We demonstrate here that immunization of children and infants with a prime-boost regimen using ChAd63 and MVA ME-TRAP induces high level T cell and antibody responses to a pre-erythrocytic malaria antigen that has previously demonstrated efficacy against CHMI in malaria naive adults and against natural infection in semi-immune adults.33, 34, 35 Levels of TRAP-specific T cells and IgG were highest in infants who received their priming immunization at 10 weeks of age and an MVA ME-TRAP boost 8 weeks later. Here, CD40LG is linked to infection.