Apart from translocations or the relevant fusion genes, recurrent mutations (e.g., NPM1, CEBPA, RUNX1) in AML can be defined by DNA methylation differences, especially for mutations in epigenetic regulator genes (e.g., DNMT3A, TET2, IDH1/2) [7, 30, 42]. This evidence concerns the gene IDH1 and acute myeloid leukemia.