Apart from translocations or the relevant fusion genes, recurrent mutations (e.g., NPM1, CEBPA, RUNX1) in AML can be defined by DNA methylation differences, especially for mutations in epigenetic regulator genes (e.g., DNMT3A, TET2, IDH1/2) [7, 30, 42]. Here, NPM1 is linked to acute myeloid leukemia.