SOX2 and acute myeloid leukemia: For example, in a study investigating the impact of global and gene-specific DNA methylation status (promoters of 5 stem cell-related transcription factor genes SOX2, OCT4, KLF4, MYC, and NANO) in AML patients treated with decitabine [65], Zhang et al. showed that patients with a high level of 5-mC had a poor prognosis after demethylation therapy, and higher methylation status of the SOX2 and OCT4 genes was associated with differential response to demethylation therapy.