Selected trials enrolled subjects with diabetes [52, 54, 57], combined hyperlipidemia [50–59, 62, 63], familial defective apoB [60], heart transplantation [61], primary dyslipoproteinemia [54], mixed dyslipidemia combined with hyper-Lp(a) [62], primary hypercholesterolemia combined with hyper-Lp(a) [63], primary hypercholesterolemia [64, 65], and primary hypertriglyceridemia [65]. The gene discussed is LPA; the disease is metabolic syndrome.