ACE and diabetes mellitus: On the other hand, for patients with acceptable eGFR and started to develop mildly increased albuminuria, timely intervention like tight control of DM and the use of angiotensin-converting-enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) can prevent or postpone the progression to moderately or severely increased albuminuria and the subsequent development of diabetic nephropathy, which in turn helps to maintain a satisfactory eGFR level.