However, CEA levels correlated only with lymph node metastasis (Additional file 3: Table S3A), while CYFRA21-1 was associated with metastasis to brain (Negative: 5.6%; moderate: 2.4%; high: 16.0%, P < 0.05), and lymph node (Negative: 41.7%; moderate: 60%; high: 74.5%; P < 0.05) (Additional file 3: Table S3B). The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.