A number of MEK inhibitors have been evaluated in clinical trials; to date, trametinib, cobimetinib, and binimetinib are the only agents in this class to demonstrate efficacy in phase 3 trials of melanoma (Flaherty et al, 2012; Larkin et al, 2014; Long et al, 2014; Robert et al, 2015; Dummer et al, 2016). Here, MAP2K7 is linked to melanoma.