MTDH and non-small cell lung carcinoma: Also, they applied MTT, TUNEL, flow cytometry assay and immunohistochemistry to verify that AEG-1 could play a pivotal role in the carcinogenesis of NSCLC and could suppress apoptosis via activating cell survival signaling, e.g., improving the level of anti-apoptotic protein Bcl-2 and the activation of PI3K/Akt pathway.