In this meta-analysis, we compared the difference of AEG-1 between clinical stage I and II and clinical stage III and IV, between with lymph node metastasis and without lymph node metastasis, between with distant metastasis and without distant metastasis, as well as between histological differentiation (Poorly) and histological differentiation (Well/Moderately), and the results may suggest the possibility of using the expression level of AEG-1 as a clinical biomarker of NSCLC. This evidence concerns the gene MTDH and non-small cell lung carcinoma.