The size of the tumor xenografts in the mock, NC and AEG-1-shRNA groups was 0.04 ±0.01, 0.02 ±0.01 and 0 cm3, respectively, indicating that the tumorigenic ability of the H460 cells was weakened by silencing AEG-1 expression (P < 0.05, Figure 12C). The gene discussed is MTDH; the disease is neoplasm.