TNFAIP3 and neoplasm: For example, the 6q23.3 region containing TNFAIP3, a negative regulator of the NF-κB signaling pathway, was significantly deleted across tumor samples (Figure 1A; FDR = 1.02E-03 using GISTIC): 50% of samples (5 of 10) demonstrated the deletion of 6q23.3, where 3 samples had a homozygous deletion (Supplementary Figure 3), and 2 had a heterozygous deletion.