Mutations in the LMNA gene, which encodes lamins A and C, cause a variety of human diseases termed laminopathies, including Hutchinson-Gilford progeria syndrome (HGPS), dilated cardiomyopathy, limb-girdle muscular dystrophy, and Emery-Dreifuss muscular dystrophy (EDMD).78 Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.