ZIKV infection of human DCs led to significant induction of IFNB1 at the transcript level, however, we observed impaired translation of type I IFN proteins despite induced protein expression of the RLRs (RIG-I, MDA5, and LGP2), STAT proteins (STAT1 and 2), and antiviral effectors (IFIT1, IFIT3, and viperin). The gene discussed is IFIH1; the disease is Zika virus infectious disease.