Quantitative analysis of immunopositive RET and GFRα1 signals in the myenteric plexus of patients with diverticulosis, DD and controls revealed a significant drop-down in fluorescence intensity of RET to 38% ± 5% for diverticulosis and to 46% ± 4% for DD, when compared to controls (Fig 5D). The gene discussed is GFRA1; the disease is diverticular disease.