ZHX1 has been reported to induce apoptosis and cell cycle arrest (G1/S) by regulating cyclin D1, cyclin E, Bcl2, Bax, and cleaved caspase-3 in gastric cancer[14], and ZHX2 overexpression was correlated with low expressions of cyclin A and cyclin E in HCC[15]. This evidence concerns the gene CCND1 and hepatocellular carcinoma.