NKX2-1 and diffuse large B-cell lymphoma: However, in marginal-zone B-cell lymphoma NKX2-3 expression is aberrantly activated via chromosomal juxtaposition to the B-cell receptor gene, and in diffuse large B-cell lymphoma activation of NKX2-1 is mediated by chromatin alterations but not via direct chromosomal rearrangement [47,55].