NKX2-3 and acute lymphoblastic leukemia: These data indicated that three genes, namely HHEX, HLX1 and NKX2-3, were physiologically expressed in HSPCs, while the analyzed T-ALL cell lines aberrantly expressed HHEX, MSX1, NKX2-5, NKX3-1, TLX1 and TLX3 as reported previously [8,10,15,16,31].