According to this procedure we identified 20 deregulated genes, seven of which (35%) are physiologically expressed during hematopoiesis/lymphopoiesis (HHEX, HLX1, MSX1, NKX2-3, NKX3-1, NKX6-3, TLX2), while 13/20 (65%) are ectopically expressed in T-ALL (DLX1, DLX2, DLX3, DLX6, LBX1, MSX2, NKX1-1, NKX2-1, NKX2-2, NKX2-5, NKX3-2, TLX1, TLX3). The gene discussed is NKX3-1; the disease is acute lymphoblastic leukemia.