This relationship was independent of BMI and was present irrespective of the presence or absence of CD14+ macrophages (CD14+ r = -0.92, p = 0.0008; CD14- r = -0.85, p = 0.001 with HOMA; CD14+ r = -0.99, p = 0.0004; CD14- r = -0.9; p = 0.001), indicating that systemic insulin resistance is associated with poor preadipocyte differentiation independent of CD14+ cells. The gene discussed is CD14; the disease is Insulin resistance.