In contrast to infected TCRβ-null mice TAP1-null mice did not show breach in the BBB (Relative values for dye-extravasation for infected vs. uninfected TAP1-nulls 1.07 +/- 0.03 vs 1.00 +/- 0.07 from 4–6 mice per group) on day 12 post-infection. The gene discussed is TAP1; the disease is infection.