Investigating toxic changes of biomarkers referred to primary glomerulonephritis revealed a substantial impact of APAP on the heparin-binding growth factor HBEGF at 8 h (Benjamini–Hochberg corrected p = 0.0026, 95% CI = [0.42, 0.96], two-sample t-test) (Fig 7E). The gene discussed is HBEGF; the disease is glomerulonephritis.