The mechanism may be related to the following factors:[11–15] (1) long-term excessive thyroid hormones produnction has direct toxicity on the liver; (2) thyrotoxicosis hastens liver glycogen and protein decomposition, which causes liver cell degeneration; (3) A hypermetabolic state leads to an increasement in organic energy consumption and liver burden. The gene discussed is TG; the disease is thyrotoxicosis.