In the latest research, polypeptide extract from scorpion venom (PESV) may inhibit the angiogenesis of Lewis lung carcinomas (LCCs) by decreasing the level of VIII, alpha-SMA, DII4, and Notch1 in the tumor microenvironment.[38] Furthermore, centipede and gecko, 2 types of traditional CM with remarkable antineoplastic activity, have been reported to induce cell cycle arrest and the apoptosis of cancer cells.[39,40]. This evidence concerns the gene NOTCH1 and cancer.