For SATB2, the core associated clinical features have remained remarkably stable since the original individuals were reported by two of this article’s authors (H.V.F. and D.R.F.)in 1999.1,2 These two girls had strikingly similar facial appearances; both had cleft palate, normal prenatal and postnatal growth, and intellectual disability most strikingly in speech and language development. This evidence concerns the gene SATB2 and Intellectual disability.