The first intragenic point mutation in SATB2 was reported in 2007, by Leoyklang et al.,7 in a 36-year-old man with a heterozygous nonsense mutation in SATB2 associated with a cleft palate, generalized osteoporosis, profound intellectual disability, epilepsy, and a jovial personality. The gene discussed is SATB2; the disease is cleft palate.