Several alternative ways to increase BIK expression have been established, such as vector-mediated BIK expression,32 adenovirus-mediated BIK expression and BIK-based gene therapy.33, 34, 35, 36 By promoting the polyadenylation of BIK mRNA, Star-PAP increases BIK expression and induces mitochondrial apoptosis of cancer cells (Figure 3b), indicating that Star-PAP overexpression may sensitize cancer cells to chemotherapy drugs. Here, BIK is linked to cancer.