It has been established that Star-PAP controls the expression of BIK, a member of the BCL-2 family proapoptotic proteins,18, 26 through regulating 3′end processing of its mRNA in HEK293 cells.9 Therefore, we inspected the relation between Star-PAP and BIK in breast cancer cells (Figure 3c). This evidence concerns the gene BCL2 and breast cancer.