Star-PAP is encoded by gene TUT1 that is ubiquitously expressed in normal human tissues and has putative family members from Schizosaccharomyces pombe to homo sapiens.6, 8 In this study, we examined the expression of Star-PAP, both mRNA and protein levels, in breast cancer cells as well as clinical breast tumors, and we observed a consistent differential Star-PAP expression existing between the normal and cancerous breast condition (Figure 1). This evidence concerns the gene TUT1 and breast neoplasm.