Immunogenic cell death (ICD) is heavily regulated and capable of activating an adaptive immune response against tumor-specific antigens.21 It is characterized by the release and/or increased expression of damage-associated molecular patterns (DAMPs), including ATP, HMGB1, heat-shock protein 90 (HSP90), and calreticulin (CRT), among other immunostimulatory molecules.22, 23, 24, 25, 26, 27, 28, 29 There is limited data evaluating the effect of RB on ICD in solid organ malignancies, including colon cancer, where there is established potential and a great need for immunotherapeutic strategies. The gene discussed is HMGB1; the disease is malignant colon neoplasm.