Overexpression of the family member KCa3.1 (IK1) was related to aberrant cell proliferation of different tumor cells, including melanoma.19, 20 TRAM-34 has been established as a selective KCa3.1 inhibitor, which avoids side effects of some other channel inhibitors, such as hepatotoxicity.21, 22 We have previously shown that TRAM-34 can act as apoptosis enhancer in melanoma cells when combined with the death ligand TRAIL (TNF-related apoptosis-inducing ligand).23 Here we demonstrate that apoptosis induction by vemurafenib in melanoma cells is strongly enhanced by TRAM-34. This evidence concerns the gene TNFSF10 and melanoma.