Similar to recently published results, we found the role of RIPK3 in the tumor microenvironment was not because of the altered immune response but the ability of tumor cells to extravasate into the lung.25 However, we found the kinase activity of RIPK1 but not RIPK3 kinase activity was important in the extravasation step of metastasis. This evidence concerns the gene RIPK3 and neoplasm.