Currently, MLKL is considered to be the essential and the only known effector protein for necroptosis.10, 11 To determine if proteins composing the necrosome were important in the reduction of tumor nodules in the lung, RIPK1 kinase dead (K45A) mice were injected with B16-F10 cells (tail i.v.)and after 14 dpi, the lungs were harvested, blinded and tumor nodules were counted. This evidence concerns the gene RIPK1 and neoplasm.