Impaired wound healing was found in Ripk3−/− mice compared with wild-type mice, characterized by a decreased MMP-9 protein expression and delayed CD31+ staining and VEGF production.45 Of the cytokines and growth factors we assayed, only MMP-9 was reduced at 24 h in the Ripk3−/− mice compared with wild-type upon tumor cell injection. This evidence concerns the gene RIPK3 and neoplasm.