These results support the idea that the hematopoietic compartment does not have a role in the loss of tumor formation in the Ripk3−/− mice similar to findings in Figure 3d and further supports observation that the kinase activity of RIPK3 in the ECs is not required for the ability of tumor cells transmigrate and tumor nodules to form in the lung (Figures 2b and c). The gene discussed is RIPK3; the disease is neoplasm.