Interestingly, in Seifert et al.22, the loss of Mincle combined with the V12K-Ras PDA did not protect, as well as the loss of RIPK3, suggesting additional factors may have a role in the ability of RIPK3 to form PDA in a V12K-Ras model. The gene discussed is CLEC4E; the disease is Patent ductus arteriosus.