Vascular permeability has been proposed as a model for tumor metastasis where vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) or CCL-2 may influence permeability.30, 31, 32 Recent data show that activation of VEGF leads to c-Src activation and change in VE-cadherin distribution allowing for increased vascular permeability and subsequent tumor metastasis.33 To determine if factors involved in vascular permeability was affected, we assayed for VEGF-A, FGF-b or TWEAK in lung homogenates of wild-type and Ripk3−/− mice injected with B16-F10 cells. This evidence concerns the gene RIPK3 and neoplasm.