A recent study has also shown that Nrf2 increases the radioresistance of cancer cells by targeting Rad51 expression in a ROS-independent manner.48 According to Kim et al.,49 Nrf2 regulates the expression of 53BP1 to protect colonic epithelial cells from ionizing radiation.49 In summary, Nrf2 may be another potential mediator for radioresistance by regulating both antioxidant capability and DNA damage repair. Here, TP53BP1 is linked to cancer.