TG2 has crucial roles in a number of both physiological and pathological events, which involve modifying its substrate proteins.39 Numerous studies that investigated the putative role of TG2 in cancers described the dual role of the protein acting either as a facilitator or attenuator of cell proliferation.40 The evidence that TG2 is activated by reactive oxygen species implies TG2 acts as a stress responder that may confer a growth advantage to cancer cells to survive in micro-environmental hypoxia.41 The gene discussed is TGM2; the disease is cancer.