Moreover, p50 and p65 form a canonical heterodimer that is known to have a dual role in the activation of NF-κB.39 And it is now well known that NF-κB is a key inflammatory pathway in the pathogenesis of DN inflammatory and fibrosis in both animal experiments and clinical studies.40, 41 In addition, inhibition of NF-κB activation reduces the expression of inflammatory cytokines to protect the rats against DN.42 Also, our previously study have showed that the interaction of NF-κB and miR-451 participates in inflammation of DN.3 However, the concrete mechanism still remains unclear. Here, NFKB1 is linked to liver dysplastic nodule.