PVT1 and liver dysplastic nodule: Two lncRNAs ENSMUST00000147869 and CYP4B1-PS1-001 have been recently reported to regulate MCs proliferation and fibrosis induced by DN.26, 27 Moreover, lncRNAs MIAT and Pvt1 are reported to participate in renal tubular epithelial injury and extracellular matrix accumulation of DN.28, 29, 30, 31 Furthermore, single-nucleotide polymorphisms of lncRNA Pvt1 contributes to susceptibility to DN.32, 33 However, the exact mechanism of lncRNAs in DN remains mysterious.